Exact(32)
Nowell, P. C. The clonal evolution of tumor cell populations.
Thus our data suggest that there is ongoing evolution of tumor clones at each site resulting in divergent tumor immunogenicity following metastasis.
It can serve as a useful tool for monitoring both the temporal evolution of tumor angiogenesis and the impact of antiangiogenic therapies.
In this paper, we design a stochastic mathematical model of the evolution of tumor metastases in an expanding cancer cell population.
In view of drug vector distribution in tumors, independent of formulation and other pharmacokinetic aspects, our results suggest that the evolution of tumor vasculature during progression may influence drug delivery efficiency.
Open image in new window Fig. 6 Effect of artemisinin on the evolution of tumor volume in mice.
Similar(28)
Kojima, Y. et al. Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.
Currently, we treat tumors with medication to target and inhibit the tumor as is, but not to prevent the future evolution of tumors into resistant forms.
"Adventures in modeling cancer evolution" Abstract: Understanding the past and future evolution of tumors is a challenging experimental and mathematical problem.
Other scientists intend to exploit the method to trace the evolution of tumors.
Thus, mutator mutations may be important for the evolution of tumors without being important in species evolution.
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