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Finally, properties of RNAs obtained by either the structure-based or the combinatorial methods are discussed in the light of the origin and evolution of the translation machinery, but also with a view to obtain new inhibitors targeting specific steps in translation.
These and other hypotheses tackle important aspects of the origin and evolution of the translation system.
Critically, it is precisely this function that must have triggered the evolution of the translation machinery.
There are several apparent "Chicken and Egg Paradoxes" in biology, most notably, the evolution of the translation system.
A new index of translation elongation ITE is formulated to facilitate studies on the efficiency and evolution of the translation machinery.
They present an intriguing new overall model of the evolution of the translation system, and highlight aspects of this model that could be tested in the laboratory.
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Similarly, the discussion on pp. 33 39 of a plausible scenario for the evolution of the modern translation system seems plausible and is more detailed than most such scenarios to be found in the literature.
We would argue similarly that peptide synthesis evolved from a more rudimentary noncoded form, and that the synthesis of increasingly more complex peptides provided the selective advantage for a stepwise evolution of the contemporary translation system (similar to the view expressed by Maizels and Weiner [ 8]).
After everyone was seated in the yellow room, a group of panelists — Alyson Waters (moderator), David Bellos, Lydia Davis, and Lorin Stein — took up the subject of the evolution of French translation over the past twenty-five years.
E-mail address GO SIGN UP Share Tweet After everyone was seated in the yellow room, a group of panelists — Alyson Waters (moderator), David Bellos, Lydia Davis, and Lorin Stein — took up the subject of the evolution of French translation over the past twenty-five years.
The current scenario for the evolution of translation in the RNA World faces formidable difficulties because, although the ribozyme catalysis of the elementary reactions required for translation has been demonstrated experimentally (Table 1), the required complex RNA-mediated functions have not.
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