The physical aging process, namely the spontaneous evolution of the thermodynamic state occurring in glasses, has been monitored in poly methyl methacrylate) (PMMA)/silica and polystyrene (PS /silica nanocomposites following the time evolution of the enthalpy by means of differential scanning calorimetry (DSC).
The molecular mechanisms behind the evolution of spontaneous antimicrobial resistance in B. cenocepacia are not known and how the multiple resistance pathways function on a global scale to allow B. cenocepacia to survive antibiotic therapy is poorly understood.
This can then be used for the survey of suitably large samples that are representative of different subjects, and it should also be easy enough to carry out repeated mapping over time (i.e., monitoring of the spontaneous evolution of clinical cases or results obtained under given treatments).
We report here the unique observation of the spontaneous evolution of two breast cancer patients with synchronous liver metastases who decided to stop trastuzumab after achieving complete response.
While we agree with reviewer 1 that it would potentially be useful to perform passive transfer experiments with IgG3 antibodies in the IgG3-deficient MRL/ lpr mouse model, such experiments are not guaranteed to recreate the in vivo conditions that obtain during the evolution of spontaneous glomerulonephritis.
Experiments using ex vivo cultured neural networks have demonstrated that the adjustment of synaptic connections is highly correlated with the development of neuronal network behavior such as the evolution of spontaneous electrical activity [ 15, 16].
Surprisingly, all samples presented one or more clusters of subclonal variants, reflecting the presence of heterogeneity with evidence of continued spontaneous evolution of the disease even in early, premalignant phases (Supplementary Table 3).
Subsequently, all former residents had to move to other districts and the long-term spontaneous evolution of the Msheireb district, as a representative of traditional neighbourhoods and their migrant communities, was replaced.
If it were true, as we have mentioned more than once previously, that (functional, aesthetic, social) order did not, in the past evolution of the human species, constitute a spontaneous event but the outcome of a project, then we would need to devote some thought to this.
