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Differences in evolution of the outcome variables among independent groups were analysed with the Kruskal-Wallis test.
A somewhat abrupt but continuous change in the evolution of the outcome over time can be modelled by including a change point in the generalised linear mixed model (GLMM).
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Furthermore adjustment for baseline values is needed so that the year 20 outcome value represents the evolution of the study outcomes over 18 years.
11 Therefore, a 36-month follow-up was subsequently carried out to follow the evolution of these outcomes.
In order to study the evolution of the various outcomes over time, and to study how those evolutions depend on patient and/or PCPs characteristics, including use of IDCT, mixed models with random patient effects were used, which correctly accounted for the clustered nature of the repeated measurements within subjects.
His "shifting balance theory" saw evolution as the outcome of differing histories of the different demes within a species where demes could merge with one another, bud off from one another, or simply go extinct.
A study defining phenotypic variations of parasite isolates at the point of clinical diagnosis could allow us to predict the evolution and the outcome of disease.
But because evolution is the outcome of the interaction between (i) genetic variation, and (ii) natural selection, the capacity to adapt is often limited by the first step – the capacity of a population to produce enough variation upon which selection can act [63].
3. Mean comparison tests for each outcome variable according to the treatment group (differences pre-post treatment in both treatment groups as well as differences between them) 4. Multivariate analysis to determine the influence of independent variables in the evolution of each outcome variable.
V = ∑ i = 1 n V i n Minority variants have been shown to be associated with various viral features, such as viral evolution, pathogenesis and the outcome of drug treatment (Nájera et al., 1995; Vignuzzi et al., 2005).
Ten years after the first QRF and DXA the patients are asked to answer a phone survey (See additional file 1) to know the evolution of the study variables and outcomes (fragility fractures).
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