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These data are consistent with the evolution of substantial volume decreases identified by manual segmentation and DBM in the thalamus and ventral midbrain.
FISH is the only currently available reliable technique that allows measurements on enough individual cells to model the evolution of substantial intratumor heterogeneity.
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An additional microsporidian, Enterocytozoon bieneusi (Akiyoshi et al. 2009), was included in this tree but excluded from subsequent analyses of gene content evolution because of substantial genomic contamination (Heinz et al. 2012; Peyretaillade et al. 2012).
Unusual deposits, mapped and logged in detail, around the summit area of Tongariro volcano, Tongariro Volcanic Centre, New Zealand indicate that the construction and evolution of a substantial portion of this andesitic stratovolcano was beneath a significant ice cap or summit glacier.
Indeed, it was showed that gene gains and gene losses contributed to the evolution of a substantial majority of orthologous sets of prokaryotic proteins [ 38- 40].
Therefore, it seems impossible to explain these patterns without invoking massive, lineage-specific gene loss and HGT, and recent quantitative analysis has suggested that these processes contributed to the evolution of a substantial majority of orthologous sets of prokaryotic proteins [ 17].
The Virus World concept is predicated on a model of early evolution whereby emergence of substantial genetic diversity antedates the advent of full-fledged cells, allowing for extensive gene mixing at this early stage of evolution.
The proportion of hotspots shared between these two groups is only 17.4%, which is a small proportion given the recent out of Africa origin of non African population, and also show that the pace of evolution of hotspots is substantial.
The ability of both of these models to predict influenza evolution rests on the presence of substantial fitness variation in the influenza A/H3N2 virus population.
Getting to this point has required substantial evolution of our lending model.
Our study found substantial evolution of SShD in the Drosophila melanogaster subgroup.
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