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We used our new dense chromosomal maps to annotate genomic rearrangements and chromosome evolution of ruminants.
A focus for future investigations is to determine whether the BSP30 gene duplications and subsequent divergence observed in cattle could have been a key step in the evolution of ruminants by facilitating adaptation to a ruminant lifestyle.
The chromosomal maps allowed us to anchor and orientate assembled genome scaffolds along the chromosomes, annotate chromosome rearrangements and thereby get a better understanding of the genome evolution of ruminants and other mammals.
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Bov-A2, along with other members of the Bov-A SINEs and Bov-B LINEs, constitutes an important marker in deciphering the evolution and phylogeny of ruminants [ 11, 19].
Communal grazing lands were managed by the local councils, consisted of experienced men (tseligas), who decided on the numbers of animals to use the land, the temporal and spatial distribution of flocks, etc. Figure 2 Evolution of farmed ruminants (heads of bovines, sheep, goats) in Greece during the last 100 years (data derived from Hellenic Statistical Authority archives).
The genetic changes underlying the evolution of the ruminant lifestyle are poorly understood.
Functionally, cattle-specific miRNAs might be associated with the insulin signalling pathway, and thus potentially have a role in the evolution of insulin resistance in ruminants.
The new CattleCyc database will contribute to understanding the evolution of mammalian metabolism and the physiology of ruminants at the systems level.
Age-calibrated trees of Bovidae are also relevant to studies seeking to establish rates of evolution within a larger context of ruminant and mammalian evolution, including, for example, the terrestrial origins of whales e.g. [ 8, 9].
However, there are two exceptions to this general pattern for ruminants as a whole: the separation of small and large ruminants and the evolution of ovine TLR2 in ibex and sheep.
In summary, we have provided the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type I IFN in ruminants.
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