Sentence examples for evolution of plaques from inspiring English sources

We interpreted these results to indicate that iatrogenic trauma to the vasculature in patients with type 2 diabetes and insulin resistance would lead to accelerated evolution of plaques vulnerable to rupture and hence subsequently increased mortality consistent with the biological behavior of vasculature in which expression of PAI-1 was increased.

We aimed to choose a virus strain for the experiments, which has relatively slow and well-controlled spreading characteristic in order to analyse the evolution of plaque size and distribution very precisely over time.

Fine mapping of actively demyelinating lesions in multiple sclerosis revealed several different zones, representing the evolution of the plaques (Figs 1A F, 2A G).

An inducible model made it possible to study the evolution of the plaques after the hAPP695 Swedish/Indiana transgene had been inactivated.

The prominent role played by neovascularization in the evolution of psoriatic plaques is underscored by the reported dose-dependent effect of neovastat, an inhibitor of angiogenesis, which resulted in improvement in psoriasis [ 22].

However, the crucial difference between the experimental models and patients is that the patients, owing to their co-morbidities, do not have sufficient growth of collaterals to counteract the evolution of the plaques, despite this accommodation window (Fig. 2C).

This model (described in words above) is conceptually divided in two main parts: a "biochemical" model describing the LDL oxidation and the immune response (e.g., effect of pro and anti-inflammatory cytokines); and a "mechanical" model describing the plaque growth and the effect of blood flow conditions on the evolution of the plaque.

Mesulam and Geula (1994) hypothesized a two-stage evolution of ß-amyloid plaques with a secondary development of local neurotoxicity due to the increase of butyrylcholinesterase at the plaque level.

They have argued for a two-stage evolution of senile amyloid plaques with a secondary development of local neurotoxicity, for which increased levels of BChE in the plaque structure may be a marker and putative toxic agent (Mesulam and Geula 1994).

Future directions of CT for plaque detection and characterisation include a more detailed morphological analysis of coronary plaque types [26], and eventually the use of molecular imaging in adjunct with contrast agents targeting specific cells that are important in the development and evolution of coronary arterial plaques [27].

Therefore, the specific role of these cells in the evolution of the senile plaques in AD is still under debate.