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Subsequent gene duplications, tissue specific expression patterns and lineage specific expansions resulted in the evolution of new networks of interaction and new biological functions associated with the maintenance of organismal complexity and homeostasis.
Our phylogenetic analysis reveals that once the rGC and sGC multidomain proteins had evolved in the animal lineage subsequent gene duplications, tissue specific expression patterns and lineage specific expansions resulted in the evolution of new networks of interaction and new biological functions associated with the maintenance of organismal complexity and homeostasis.
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Larger brains have more neurons and tend to become more modularized, which may facilitate the evolution of new cognitive networks.
This is hypothesized to lead to both an increase in morphological complexity, via the evolution of novel features, and an increase in proteomic network complexity, through the establishment of new network interactions [ 3- 5].
For instance, views on novel retrotransposon insertions in humans range from considering them as essentially evolutionary neutral as long as they do not target exons [ 9] to being important driving forces behind the evolution of new gene regulatory networks [ 10].
Changes in these networks are thus coupled to the evolution of new functions and functional relationships in the organism.
They can even spur the evolution of new diversity.
Jensen, R.A. Enzyme recruitment in evolution of new function.
But it is inviting the evolution of new thinking.
These observations raise the possibility that this circuit has been conserved as a unit over millions of years of evolution and redeployed in new networks under completely different circumstances.
These sequence features give to LMs an evolutionary plasticity and an important role in the evolution of cellular networks by the addition of new functionality to proteins [1].
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