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The effects of density dependence on the evolution of lifespan and mortality remain largely unexplored.
Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive.
We argue that fitness of alternative strategies under a range of different demographic structures leads to flat, as opposed to rugged, landscapes and that these flat fitness surfaces are important in the evolution of lifespan and senescence.
Although the plasticity of these sex differences will make it challenging to generalize from invertebrate to vertebrate systems, studies in nematodes have enabled empirical evaluation of predictions regarding the evolution of lifespan.
Explanations of the evolution of lifespan beyond the age of female menopause have proven difficult to describe as explicit genetic models.
Male and female longevity are only weakly genetically correlated, thereby providing considerable scope for independent evolution of lifespan in the sexes.
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To unravel the mechanisms underlying the evolution of long lifespan, a large number of natural and genetically tractable systems have been employed in ageing research [1].
Thus, there appears to be a sex-specific evolution of reduced lifespan in the females of the selected populations.
One major target of these adaptive processes is the evolution of life history traits such as lifespan, growth, development and plasticity [ 6, 7].
Body weight exhibited greater constraints and probably influenced evolution of other life histories, such as lifespan and maturation time.
Increased late-life reproduction by men has increased human longevity relative to other higher primates (the patriarch hypothesis) [ 18]; the design of the ovary has constrained the evolution of longer reproductive lifespan in women [ 65]; and antagonistic pleiotropy acting on testicular function has decreased male lifespan [ 35].
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