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The evolution of headache for each subject is shown in Table 4.
This led to close observation of the evolution of headache by charting the annual course.
A correlation was subsequently observed between the evolution of headache and the presence of anxiety or depression.
As shown by this systematic review, description of the evolution of headache from childhood to adulthood has been a focus of interest for several authors.
More prospective studies following the evolution of headache into adulthood are required in order to achieve a deeper awareness of the different phenotypes of headache.
A strict relationship between migraine and psychiatric factors has been suggested, but the exact role and the influence on evolution of headache is unknown.
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Also, to describe the evolution of headaches over time, we specifically collected information on subjects' headaches at multiple time-points before and after EVT.
Although no long term studies exist on the natural evolution of cough headache, it seems that most of the primary cough headache patients remit spontaneously after maximum 4 years, however, patients with a disease duration of 12 years and more have been described [5].
The case of a 7-year old female who fulfilled the IHS diagnostic criteria for episodic CH was reviewed, but the paper in question did not provide data about evolution of the headache [31].
In patients with episodic migraine, the presence of psychiatric disorders, such as anxiety or depression or both, facilitate the evolution of the headache into the chronic form [8]. Patients with migraine, anxiety, and chronic depression also had poor health-related quality of life (QOL) [9].
The availability of data about the evolution of primary headaches over a period of time is important, both from a clinical and a public health perspective.
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