Sentence examples for evolution of a genetically from inspiring English sources

Using genome sequencing, we characterized the somatic evolution of a genetically engineered mouse model (GEMM) of SCLC initiated by loss of Trp53 and Rb1.

Metastasis represents the definite cause of 90% of deaths from solid tumors and it emerges from the somatic evolution of a genetically variegated cancer-cell population under the selective pressures of an environment that imposes tight rules on cellular behavior.

Finally, our results also provide support for the hypothesis that HGT has been a dominant force in adaptation of L. casei to new habitats and lifestyles, and that evolution of a genetically distinct and geographically distributed cluster of L. casei cheese specialists has been accompanied by extensive decay of genes associated with carbohydrate utilization [ 28].

The evolution of an entirely distinct genetically-encoded amino acid for such a singular and specialized function is unprecedented in any other known translation systems.

In addition, many observations in wild populations suggest that in multiple cases an ancestral alternative phenotype may have facilitated the evolution of new, genetically fixed adaptive traits [ 17- 19, 30- 36, 40].

A recent modeling study has reported that point mutations in the H5 gene may have led to the evolution of 20 genetically and potentially antigenically distinct strains [ 29].

As addition to the developed concept, the authors have designed a computer simulation of somatic cancer evolution of genetically unstable cells based on a very simplified mechanism of unequal sister chromatid exchange (USCE) in order to provide a crude impression of possible restrictive or permissive effects of the cancer genome architecture on cancer cell evolution.

There is ample evidence, both in vivo and in vitro, that pigs serve as facile hosts for the genetic reassortment of influenza A viruses facilitating the evolution of genetically novel viral strains [ 42– 42].

The introduction history of this mosquito is not precisely known, but mitochondrial haplotype analysis supports the hypothesis of a single introduction (Usmani-Brown et al. 2009), making this another possible example of a genetically restricted population undergoing rapid CDL evolution.

This failure to cure disease means that tumor cells found a third way around PI3K inhibition, and it is intriguing to speculate that this third wave of resistance may be due to the evolution of genetically resistant clones that, for example, harbor a myc amplification [ 13].

We examined the evolution of genetically integrated traits in digital organisms self-replicating corganisms self-replicatingte, computer adaprogramsevolve in a virthat world.