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The final step is to perform the evolution itself (contour evolution module).
A two dimensional (2D) morphological model which contains grid generation module, circulation module, wave module, transport module and bed evolution module has been developed and validated.
A controllable SIM evolution module was devised based on a genetic toggle switch in Escherichia coli.
This can be achieved by equipping cells with a synthetic evolution module.
Finally, the evolution module was applied to produce autonomous adaptive evolution of E. coli under n-butanol stress.
The evolution module was designed to increase the cellular mutation rate in response to stress signals, based on a new evolutionary theory of stress-induced mutagenesis (SIM).
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Arboretum uses a generative probabilistic model of the evolution of module membership of a given gene, starting from the last common ancestor (LCA) of a set of species and probabilistically propagating this membership down the branches of the phylogenetic tree to the leaf nodes.
Nonetheless, the results that were significant tended to support the constraint hypothesis, that integration limits variation, and thus morphological evolution, within modules.
For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new arrangements that may benefit their carrier.
Some felt that "despite the great personal evolution through the module, there are still aspects in which my evolution could have been better", but still "recommend further bioinformatics activities functioning like this one".
Alternatively, the same correlations may coordinate and perhaps accelerate evolution of a module [43], which, assuming that environmental conditions and selection pressures are comparable, would be expected to result in more rapid and thus greater diffusion through possible morphospace.
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