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Gould's illustrations of Darwin's finches were a major contribution to the theory of evolution at a time when Enlightenment and Romanticism converged, according to Harris, "creating an emphasis on art that was both accurate to the creature's habitat and natural behaviors but also beautiful".
Importantly for our arguments here, the tree metaphor came to be connected with the theory of evolution at a time before biologists had any ideas about the mechanisms underlying the principle of natural variation.
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There is increasing evidence that evolution occurs at a time scale relevant to population dynamics and natural resource management (e.g., Hendry et al. 2000; Conover and Munch 2002).
One popular homogenous model is the global Ornstein-Uhlenbeck model of trait evolution [ 73], in which the direction and rate of evolution at any time depends upon a selection coefficient and the degree of deviation of the trait's current value from some global optimum or "phylogenetic mean".
Many offer a glimpse into the evolution of town planning at a time when anything seemed possible.
The evolution of CRM comes at a time of growth but also maturation of the internet: consumers expect better and more personalised responses, moving away from "super robotic" stock responses, in the words of Intercom's co-founder and CEO Eoghan McCabe (who hails, along with the other three co-founders, from Dublin).
The utility of this approach depends on the rate constancy of molecular evolution at a genetic locus across time and across lineages.
This longitudinal study has allowed the description of gait pattern evolutions in GRMD dogs at a time when the disease becomes symptomatic, and has identified quantifiable and sequentially impaired gait variables.
It is difficult to study these questions with in vivo animal models that allow only limited experimental access to the lesion evolution at serial time points after an acute SCI always produced, for ethical reasons, under general anesthesia that might partially constrain damage severity.
These issues are in a stage of evolution at the time of this writing, but many have great relevance to development of DMDT in Alzheimer's disease (AD).
In order to shed light to the temporal variation of selective constraints acting on duplicated genes following their duplication, we focused on the evolution of fairly recent duplicated genes at a time scale appropriate for coding sequence evolution rates analysis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com