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The pain produced is typically burning, tingling or 'electric' in character, and may be accompanied by allodynia – in which normally non-painful stimuli evoke pain – and hyperalgesia 18. Neuropathic pain tends to be more severe than nociceptive pain and also more difficult to treat 26.
If normally non-painful warm or cold stimuli evoke pain, the patient experiences thermal hyperalgesia.
5-HT does not only evoke pain directly by 5-HT3-receptors, but also interacts with other substances in the chemical milieu around nociceptors.
Yet Garner's sculptures evoke pain and suffering, with a poignant effect upon viewers.
She carries the most dramatic elements of the work, and her expressions evoke pain, regret, contentment, nostalgia, and wistfulness: whatever the second requires.
Words simply "are" until the words evoke pain; it can be as few as 5, 10 or 15 words that change the direction of the wind from a balmy summer breeze to a frigid, shrieking gale-force wind that wreaks havoc with our emotions.
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The soft brush and the pinprick stimulation of the skin did not evoke pains (namely dynamic mechanical allodynia and hyperalgesia).
Symptoms indicating hypersensitivity include a spontaneously occurring sensation, termed pesthesia, increased perception of pain for a given stimulus level, termed hyperalgesia, and a situation where a normally non-painful stimulus evokes pain, termed allodynia.
All patients had moderate or severe spontaneous pain as well as evoked pain to a normally non-painful stimulus (brush-induced allodynia).
In our patient allodynia evoked by brushing or pressure on the painful area was present before SCS was tested and evoked pain scores were partially relieved by SCS, according to the NPSI.
Mice injected with PC3N-A6-WT cells developed movement evoked pain whereas mice injected with PC3N-A6-RR cellshoweded no movement-evoked pain, with limb use ratings the same as control animals (Fig. 4c).
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