Although the oligodendrocyte and the axon are the evident targets in cerebral X-ALD, the loss of microglia and/or abnormal microglia function could impair the ability to provide neuroprotective factors to deficient oligodendrocytes [ 53].
It can continue to stage elaborate shock-and-awe spectacles, but if, as is increasingly evident, the target audience refuses to be impressed by them, they are rendered utterly futile - even dangerously counterproductive.
In each of the incidents, investigators concluded that there was "either no evident military target or that the attack failed to distinguish civilians from military objectives".
Thus far there are no evident downstream target molecules that are strictly regulated by FLCN.
From the crystal structures of PhBCCP and EcBCCP, it was evident that target lysine is located at the type 1 β- turn [11], [25].
A similar pattern was evident with target digit 13; Year 1 children had a mean error which was significantly higher than both Years 2 and 3 (p < 0.01).
The site may be a bank or a bus station or a concert hall — or an ordinary block with no self-evident potential target.
ATRX-ADD, AIRE-PHD and ING2-PHD bound three different PTM states, H3K9me3, H3K4unmod and H3K4me3, respectively, with no evident off-targets.
When this became evident, we targeted recruitment at maternal and child health centres in geographic areas that contained more women who had experienced public care.
In melanoma-bearing HGF+ mice, no microscopic evidence of pigmented micrometastases was evident in potential target organs for metastasis (data not shown).
