The association of LMP with Mtb cytotoxicity yet no evident requirement for cathepsins directed our attention to other lysosomal hydrolases.
Even in controlled laboratory conditions where selective pressures are expected to be reduced since animals are fed ad libidum, a functional mandible is an evident requirement.
Krantz and co-workers [ 51] observed a similar trend in S. cerevisiae chemostats under anaerobic osmo-stress conditions, and assumed a co-regulation with general stress response genes (like CCT1), however, without any evident requirement.
The N.C.A.A. rule book mandates that basketballs must meet certain seemingly self-evident requirements to ensure some level of uniformity.
These may seem like self-evident requirements for doing a job well, but I was surprised to find how my abilities stood out compared to my peers at Columbia.
Indeed from the standpoint of modern physics the existence of rigid bodies and rigid body motion is not a fundamental self-evident requirement anymore, but only a special property that obtains in a definite limiting case of the physics of classical mechanics and geometry.
Students' views of professionalism included being proficient in biomedicine, almost considered as a self-evident requirement.
As Hennig (1966, 165) writes, "if systematics is to be a science it must bow to the self-evident requirement that objects to which the same label is given must be comparable in some way".
Apart from the evident structural requirements provided by a plethora of protein-protein interactions, there are a large number of transient protein-protein interactions that control and regulate a large number of cellular processes.
This is evident from the requirement that a state be in a "time of public emergency that threatens the life of the nation" before it may make derogations.
It is therefore evident that another requirement - for the successful use of proof techniques in the development of systems from formal descriptions - is the availability of software tools which support the manipu lation of large bodies of formulae and help the user in the design of the proofs themselves.
