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The association of LMP with Mtb cytotoxicity yet no evident requirement for cathepsins directed our attention to other lysosomal hydrolases.
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These may seem like self-evident requirements for doing a job well, but I was surprised to find how my abilities stood out compared to my peers at Columbia.
It is therefore evident that another requirement - for the successful use of proof techniques in the development of systems from formal descriptions - is the availability of software tools which support the manipu lation of large bodies of formulae and help the user in the design of the proofs themselves.
As diseases such as malaria come under improved control, the real impact of these common and under-recognized infections will become evident, as will the requirement for the strategies and allocation of resources for their control.
It is therefore evident that the minimum requirement for RIG-I to initiate an interferon response is a single-RNA duplex terminus (preferably containing a 5′-triphosphate) at the end of at least 10 base pairs.
For normal myogenesis to occur, both in vitro and in vivo, an absolute requirement for MYOGENIN is evident.
Importantly, the results of the EMSA and ChIP experiments provide strong support for the idea that the requirement for Elba activity evident in the RNAi knockdowns reflects a direct role in insulating activity rather than indirect role.
The increased incidence of anaemia was also evident in a 32% increase in transfusion requirement for the placebo arm over marimastat.
It has become evident that determination of suitable normalization standards is a requirement for the use of this method as it is applied toward any new experimental model.
It is abundantly evident that the synthesis of complex sugars was a requirement for the evolution of organisms from the very beginning (Varki 2011).
On the other hand, some disadvantages for scale-up are also evident, such as the need for specialised instrumentation and the requirement for the optimisation of multiple parameters for complex sample analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com