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The recognition of ADEs by medical teams was substantial for those ADEs with evident causality and with clinically apparent and severe consequences.
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Thus our data add to existing data and provide strong evidence for causality of the TZD's effect because of its magnitude and because of no similar cumulative effect with other glucose-lowering drug classes being evident.
A 1999 review indicated smoking as a weak risk indicator but not a cause of NSP, and signs of causality were evident only in the study with the largest sample, >30,000 subjects.
This is evident in the plots, where causality maps fail to resemble the real causality connections.
In some cases, the causality is self-evident if the variant leads to severe loss of function and is located in a gene known to cause the phenotype of interest.
However, reverse causality due to clinically evident diabetes was a less likely explanation because the analyses only included incident cases diagnosed at least 3 years after the exposure assessment; furthermore, both associations were barely changed in sensitivity analyses among apparently healthy participants at baseline.
The cross-sectional design of the current study limits our ability to infer causality, particularly as flexion limitations were also evident in the unaffected wrist of the unilaterally affected UEMSD subjects.
The principle of causality, so deeply embedded in humans' minds that it has been thought of as immediately evident, is the very foundation not only of all three monotheistic world religions but also of the first staggering steps of science [ de nihilo nihil (nothing can be born of nothing); Lucretius 1951].
While acknowledging the importance of identifying psychological markers and more specifically, taking as reference the relationships between depression and frailty, the complexity of this investigation is evident in as far as these two conditions can overlap, hampering the identification of mutual influence or the direction of causality.
The causality seems obvious.
Causality kept escaping her.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com