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Using a combination of flow cytometry, polarographic and molecular analyses, we evidenced a marked decrease in the cardiolipin content of R1H cells cultured in growth and differentiation media, together with a significant increase in the content of mitochondrial biogenesis factors and mitochondrial respiratory chain proteins.
In addition, the limited nuclear staining revealed with an anti-P65 NF- κB subunit Ab, evidenced a marked decrease in NF- κB activation in tumour cells of mice treated with both daunorubicin and rhGH, compared to the daunorubicin-treated group (P<0.0001).
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There was a skew away from a TH2 phenotype towards a TH1 phenotype as evidenced by a marked decrease in GATA3 and IL4R with constant levels of TBX21 expression as described previously [45].
The location homologous to TASK-2 residuesidue corresponds to V221 in TASK-3, and its mutation to histidine led to pore collapse, as evidenced by a marked decrease in K+/Na+ permeability ratio and low currents in low K+ medium.
Of significant interest, depletion of endogenous GADD34 in mice brain significantly rescued TBI-induced cell death, as evidenced by a marked decrease in the number of TUNEL-positive cells.
TPO test performed after sulphation of the catalytic filter evidenced a marked loss of activity.
The data provide clear evidence for a marked decrease of TG during cardiac surgery followed by an excess restoration in the postoperative phase.
Our data provide a solid evidence of a marked decrease in the prevalence of class resistance among treated individuals in Italy, as observed from a retrospective analysis including 49 clinical centres participating in the ARCA cohort during the last decade.
However, the movies captured of dilating, leaky vessels clearly demonstrate a marked decrease in RBC velocities.
These mice show a marked decrease in NMDA (N-methyl-d-aspartate) glutamate receptor (NMDAR) function.
Friedreich ataxia patients show a marked decrease in both frataxin mRNA and protein levels [1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com