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Appropriate medications in older people have a clear evidence-based indication, are well tolerated and are cost-effective.
Furthermore, over 70% of patients with an evidence-based indication for oral anticoagulation received such therapy, a high proportion compared to other surveys.
Other well-described applications, but without sufficient evidence-based indication, included suspected infection of intravascular devices, pacemakers, and catheters [ 45– 45].
Here, potentially inappropriate medications refers to "medications [that] have no clear evidence-based indication, carry a substantially higher risk of adverse side-effects or [are] not cost-effective (e.g. over prescribing)" [ 86].
[ 21] A 1-day survey at an Irish hospital revealed that 30% of patients were on PPI medication; of these, 71% were started on PPIs in hospital and 33% had no evidence-based indication [ 15].
Some of the midwives added that induction in patients with no evidence-based indication may also increase the C-section rate, "Induction is equal to increased C-section rate".
Similar(52)
In the absence of evidence-based indications, the choice of preventive agent in MOH patients should be based on the primary headache type (migraine or TTH), the drug side-effect profile, the presence of any comorbid and coexistent conditions, and the patient's preferences and previous therapeutic experiences [15].
Medication overuse headache (MOH) is a severe burden to sufferers and its treatment has few evidence-based indications.
MOH is a considerable burden for sufferers; its pathophysiology is unclear and its treatment has few evidence-based indications [1, 6, 7].
There are no evidence-based indications supporting the use of specific preventive drugs in MOH (valproic acid as well as topiramate have been shown to have beneficial effects in the prophylactic treatment of chronic migraine, complicated by excessive analgesic intake in open-label and double-blind trials).
Hence, the LTD of these three evidence-based indications represents 67% of current usage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com