For such tools to be of "clinical utility" [ 34] it is of importance that the evidence is generated in general practice under conditions that resemble normal clinical practice as closely as possible, which we believe that data collection through data capture offers.
There is a large body of evidence being generated in vitro and in vivo to demonstrate that vitamin D influences the innate and adaptive immune system.
Ideally, more scientific evidence is generated in the future for the production of more defined recommendations, e.g., estimated average requirements, as opposed to adequate intakes.
Given the increasing promotion of acceptance, and rejection of suppression, especially in clinical practice, it is important that experimental evidence is generated in the laboratory to examine these different strategies in both healthy and clinical populations.
A systematic review of the evidence for effectiveness of HIV palliative care found that it improves anxiety, pain, symptoms, and insight but that the evidence was generated almost exclusively in the pre-ART era and in high income countries [ 24].
In this context, even biomarkers that have only a low level of evidence linking them with specific therapeutics or evidence that was generated in another type of cancer become highly relevant for treatment selection.
Additional evidence to support this concept was generated in experiments in which co-administration of VLPs with a plasmid designed to express HPV16 E6 oncoprotein was associated with significant enhancement of plasmid-encoded E6-specific cellular immune responses.
For the first time, we provide evidence that a triple chimera was generated in vivo and integrated into the M. grisea genome.
The genomic composition of the flanking region of rhesus monkey SNORA24b is evidence that this snoRNA locus was generated in an RNA-mediated retro-transposition event and that the transposed unit originated from a partially processed hnRNA of snhg8.
To some extent, this reflects the experience with iCCM: the initial evidence for community-based treatment was generated in South Asia followed by best practice policies developed at the global level (Dalglish, George et al. this issue) and promoted at the national level through advocacy, joint statements and guidelines and study trips.
