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However there is a dearth of evidence; outcome studies are small scale for example [ 15] or limited to recidivism [ 16].
The study aims to assess the clinical evidence, outcome and cost of off-label use of medicines in the hospital setting.
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We evaluated whether guidelines for the different malignancies differed among themselves in the use of grading, aspects of the production and implementation process, timeliness, utilization of randomized evidence, outcomes discussed, and stance towards use of chemotherapy.
Intervention evidence outcomes were grouped by type.
Criteria guiding final selection of outcomes included: outcomes with the strongest research evidence, outcomes feasible to measure in a short time frame, and outcomes relevant to priorities at participating organizations.
Only four studies with iron cosupplementation reported mortality outcomes, and evidence of outcome reporting bias for diarrhoea incidence leads to cautious interpretation of differences in this outcome.
Table 2 presents our GRADE [27] assessment of the quality of evidence by outcome.
We assessed the quality of evidence by outcome using the GRADE methodology.
We assessed the quality of evidence by outcome using the GRADE methodology [ 23].
Recently, more convincing evidence on outcome reporting bias has been published [ 11- 13].
We also assessed the quality of evidence per outcome with the GRADE tool.
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CEO of Professional Science Editing for Scientists @ prosciediting.com