Exact(1)
Little boys were often punished for crying, and any evidence of rage in a little girl was swiftly curtailed by long periods alone in a room, or admonitions that she would go to Hell.
Similar(59)
In contrast to the expression of RAGE in RAGE +/+ mice, no RAGE protein was detected in the lungs of RAGE-/ mice.
The evidence that inhibition of RAGE may be beneficial in sepsis is derived from what is, thus far, a limited number of studies.
Ligand-RAGE interaction activates monocytes/macrophages, and recent studies provide compelling evidence for the role of RAGE in effective T-lymphocyte priming.
Studies with Rage-deficient mice provided further in vivo evidence for the central role of RAGE in initiation and perpetuation of immune responses [ 18].
Our findings have provided the first evidence of the clinical relevance and function of RAGE in HCC, namely differentiation-associated RAGE expression that confers a hypoxia-resistant phenotype.
A growing body of evidence demonstrates that increased expression of RAGE allows for more profound RAGE-induced cellular perturbation.
Our study provides preliminary evidence that the 82S allele of RAGE is a risk factor for AAA.
Evidence of involvement of ligands of RAGE and HMGB1 in host defense in E. coli abdominal sepsis was recently published by our laboratory [ 43].
In summary, we provide substantial evidence of the protective effect of RAGE depletion on AGE-induced alterations in synaptic plasticity and density.
Indeed, the usage of Rage-deficient mice (Rage-/) in well-established mouse models of inflammation-associated carcinogenesis, such as chemically induced skin carcinogenesis and colitis-associated cancer, provided direct genetic evidence for a novel role of Rage signalling in linking chronic inflammation and cancer [ 20, 48].
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