In four of the SSc-associated regions with evidence for selection, known pathogens have been implicated as the selective pressure.
Overall, there is compelling evidence for selection against ecotypes outside their natural distribution range, indicating differential selective regimes across habitats.
"We found a list of 20 genes showing evidence for selection in Tibet - but one stood out: EPAS1".
However, there is increasing evidence for selection pressure at silent sites due to constraints of RNA splicing.
This locus had no evidence for selection in non-Thoroughbreds.
The advantage of this approach, however, is that significant differences represent robust evidence for selection.
Only Tajima's D test provided evidence for selection in 16S rRNA and tRNA-Cys.
This integration pattern provides evidence for selection against CfERVs in sense orientation relative to chromosomal genes.
Within-gene heterogeneity in divergence, measured by FST, is evidence for selection [52].
In each of these cases, the evidence for selection on the gene was very strong.
NEG-POS pairs can be interpreted as evidence for selection for generalists rather than for locally adapted specialists.
