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Randomized studies help us to understand some things, but they are only one piece of the picture in "triangulating" evidence for programming.
Our study provides novel evidence for programming effects induced by glucocorticoids (GCs) on NSCs and supports the idea that fetal exposure to endogenous or exogenous GCs is likely to result in long-term consequences that may predispose to neurodevelopmental and/or neurodegenerative disorders.
In conclusion, our data provide novel evidence for programming effects induced by Dex in NSCs and support the idea that conditions associated with fetal exposure to high levels of GCs are likely to have long-term consequences that may predispose to neurodevelopmental disorders and/or to neurodegenerative processes.
Writing and analysis time for CWK is partially supported by the STEP UP (Strengthening Evidence for Programming on Unintended Pregnancy) Research Programme Consortium.
Data analysis for this paper was partly supported by UKaid from the Department for International Development DFIDD) through the STEP UP (Strengthening Evidence for Programming on Unintended Pregnancy) Research Programme Consortium.
We also acknowledge support from the STEP UP (Strengthening Evidence for Programming on Unintended Pregnancy) Research Programme Consortium, funded by UK aid from the UK Government (Grant SR1109D-6).
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In addition, evidence for programmed translational frameshifting, another regulatory mechanism, can be found in six A. asiaticus IS elements (Table 2).
A series of studies in Oklahoma, one of two states offering free prekindergarten to all children, produced evidence for program effectiveness.
Important differences, common practices, common problems, evidence or lack of evidence for program specifics were noted.
A remaining challenge or next step is to engage decision-makers in building their capacity to effectively use the available research evidence for program development purposes.
This information has enabled states parties to measure progress and identify where improvements are needed, thereby providing evidence for program planning, recommendations, and decision making.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com