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Thus, the CER presented provides evidence for comparison of these most commonly used doses of allopurinol, not all allopurinol doses.
38 Our analysis plans to examine all errors, and procedural, legal and clinical error rates separately, and thus will provide evidence for comparison to settings with electronic prescribing.
Therefore, if CDR had considered indirect and/or mixed-treatment evidence for comparison with beta-interferon and glatiramer acetate, this evidence could potentially have changed CDR's decision on natalizumab from that of rejection of reimbursement to one recommending reimbursement.
In summary, we tested the methods using both a test of the marginal distributions by group and the differences at the individual pairs in an attempt to provide methodological evidence for comparison group selection.
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It is a commonplace that prospectively randomized, controlled trials provide the highest level of evidence for comparisons of alternative types of treatment and for defining standards of care.
It will, however, provide an evidence base for comparison in future studies.
With this body of evidence available for comparison it would seem logical to explore those significant factors already identified.
Next, we fitted a network meta-analysis model for each outcome separately, 22 combining direct evidence for each comparison (eg, from studies comparing interventions A with B) with indirect evidence (eg, from studies comparing A with C and studies comparing B with C), for all pair-wise comparisons simultaneously.
23, 24 Numerous reviews have been conducted to provide evidence for this comparison, including a recent Cochrane systematic review comparing urinary and recombinant gonadotrophins.
There was no evidence for the comparison between unimodal and multimodal approach.
The strength of evidence for this comparison is considered moderate.
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