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An assumption of MTC models is that direct and indirect sources of evidence estimate the same true treatment effect across the network.
We checked this assumption by conventional pairwise meta-analyses and by removing the constraint that direct and indirect evidence estimate the same effect.
This assumption of "consistency" 17 underpins the validity of a network meta-analysis and is akin to an assumption that the direct and indirect evidence estimate the same underlying treatment effect variable.
Meta-analysis is a well-established method to systematically evaluate available evidence, estimate an overall-treatment effect and explore sources of heterogeneity in reported findings (Egger et al, 1997).
The systematic overviews will assess the quality of the available evidence, estimate the magnitude of potential benefits, identify those tests with good predictive value and help formulate practice recommendations.
Similar(54)
On one hand, scoring algorithms, such as Z-scores, assign a score to each evidence estimating the "outlierness".
In the absence of such evidence, estimating the theoretical herd immunity effects of BCG is of little utility [ 62].
However, despite the prevalence of this disorder, there is relatively little published evidence estimating the economic and humanistic burden of illness in patients with GAD in Europe.
Our approach integrates sources of evidence including allele frequency, amino acid conservation, predictors based on physicochemical properties, and gene- and domain-specific effects, with odds ratios associated with each source of evidence estimated from training data specific to each syndrome.
We tested numerous combinations of 33 input variables based on theory and empirical evidence estimating each of our three output measures – total life expectancy, life expectancy at age 60 for males, and life expectancy at age 60 for females.
53 We will present our key findings in a 'summary of findings' table using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, 54 addressing the quality of evidence, estimated effect sizes, and the secondary objectives outlined above.
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