Fourth, there is evidence that durable assets are, in fact, being created, contrary to the common perception that NREGA is a hole digging and a hole filling program.
As a single agent it is well-tolerated [16] and shows evidence of durable responses in patients with recurrent gliomas [17], [18].
89 This was well tolerated, with preliminary evidence of durable antitumor activity.
On the other hand, there is evidence for durable effects in people with prediabetes or early type 2 diabetes (8).
On the basis of DLTs, an acceptable safety profile, PK, and evidence of durable antitumour activity, aflibercept 6 mg kg−1 with docetaxel 75 mg m−2 and cisplatin 75 mg m−2 every 3 weeks was selected as the RP2D.
The benefits of former intensive insulin treatment persisted for 13 14 years after DCCT closeout and provide evidence of a durable effect of prior intensive treatment on neuropathy.
Moreover, the benefits of former intensive insulin treatment persisted for 13‐14 years after the DCCT closeout and provide evidence of a durable effect of prior intensive treatment on both peripheral [ 12] and autonomic neuropathy [ 13].
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs.
Initally, it was thought that the presence of CD25 was required for entry of the drug into the malignant T-cells, however, recent evidence has shown durable responses in patients with CD25− disease.
In the Diabetes Control and Complications Trial (DCCT) and Epidemiology of Diabetes Interventions and Complications Study (EDIC) study, the benefits of previous intensive insulin treatment persisted for 13 14 years after DCCT closeout and provided further evidence of a durable effect of prior intensive treatment and that good glycemic control is important to prevent development of neuropathy (8).
