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Heatmaps for every dataset (Supplementary Fig. 21).

After cross-dating the ring-width time series across every core (Supplementary Table 1), 16 cores were selected for cellulose δ18O analysis following standard protocols (Methods).

> MTR assigned more reads than LCA for each taxon detected by both the methods, at every rank (Supplementary Figs S19 S30).

Next, we calculated the minimum number of recombination events (rmin) for every gene (supplementary table S2, Supplementary Material online) using the four-gamete test, a simple method locating a pair of segregating sites with four haplotypes (Materials and Methods).

For this sample of nonhuman primates, we found an overall mean rate of agonism (± standard error [SE]) of 0.61±0.09 SE interactions per female per hour, or slightly more than 1 interaction every 2h (Supplementary Figure S2).

In second cluster analysis we compared the samples with a wider set of drugs filtering out drugs that were not used in all drug screens or showed low activity in every sample (Supplementary Figure 2).

Every piece of Supplementary Information must be mentioned at least once in the main article.

Curtin also sees value in enabling parents, who spend billions every year on supplementary education, to securely share their child's school data with outside specialists to create tailored instruction.

While ALTmax will not be reached every thaw season (Supplementary Note 1), it is the infrequent, warmer-than-normal summers that can reanimate and mix with pore ice that froze at intermediate thaw depths (<ALTmax) during prior, cooler summers.

Analysis of genome-wide variation revealed that each of the 182 isolates on average contain 65,629 heterozygous SNPs (1 heterozygous SNP every 204 bp, Supplementary Data 1) and 14,189 heterozygous insertion-deletion events (indels), which is in agreement with previous genomic analysis17.

However, since the density of enzyme molecules moving on crystalline chitin was high and thereby it was difficult to distinguish the individual molecules among the frames, we constructed a kymograph of sliced images and tracked the position of every molecule from Supplementary Movie 1 (Fig. 2c).

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