We propose that the object D-factor, as yet a hypothetical factor, is the instrument that governs the Checkpoint process.
Therefore, we extend the core network of Oct4, Sox2 and Nanog by adding a hypothetical factor X (compare Materials and Methods).
Whether this hypothetical factor is still on the increase or has passed its peak is unknown.
This mechanism is supported by experimental results although the hypothetical factor has not been identified [ 27, 28].
In what follows, we use stochastic modelling to examine the contribution of the hypothetical Factor X on GCN4 control, and the interplay between Factor X and ternary complex.
As per the hypothetical factor structure originally proposed by Ware, Kosinski and Keller [ 38], orthogonal models were evaluated for both solutions.
In what follows, we use stochastic modelling to examine the contributions of both ternary complex and the hypothetical Factor X on GCN4 control.
If such a hypothetical factor was present in the blood, he reasoned that he could test for its presence by linking the blood supplies of the animals.
It is further predicted that the binding of this hypothetical factor to Merlin-CTD can be disrupted or at least weakened by Ser518 phosphorylation, which thus converts the phosphorylated Merlin back to its functionally dormant form.
The two hypothetical factors of the goalkeeper-model should correspond to events during embryonic or larval development.
If this conjecture proves correct, it will be important to identify the proteases responsible for cleavage of PrPC, here termed α-PrPases, and any hypothetical factors that may control their activity.
