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33– 35 Although guidelines do not explicitly advise discussion of ULT with every gout patient around the time of diagnosis, the majority of patients will have recommended specific indications (eg, further attacks, 27 renal impairment, 36 required chronic diuretic use, 36 nephrolithiasis, 37 peripheral joint damage or tophi 38) at diagnosis or within 6 12 months.
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22 23 25 26 As these comorbidities are themselves major risk factors for cardiovascular disease, every diagnosis of gout should act as a "red flag" to alert doctors to assess patients for cardiovascular risk.
About two out of every five patients with gout in this population had CKD.
In patients older than 65 years, the sex gap narrows to one woman to every three men with gout and/or hyperuricemia (3:1 ratio).
In patients older than 65 years, the sex gap narrows to one woman to every three men with gout and/or hyperuricemia [ 5].
The low adherers were not convinced that ULT was needed every day or was helping their gout vs. high adherers who had the very opposite experience and perception, that is, the ULT helped them avoid severe pain and suffering.
The study examined the efficacy of pegloticase in a cohort of 30 patients with severe gout (93% tophaceous) utilizing an every 3-week infusion regimen, rather than the every 2-week schedule employed in previously published phase 3 trials.
This is no small point; patients who are placed on pegloticase generally have severe, long-standing, and refractory gout, and should be given every chance to optimize their response to a potentially transformative therapy.
It's like Ocean's 11 except every character has had a serious battle with gout in the past.
I confess I haven't read every word of every Conrad novel, but this information comes from the magisterial volume "Gout: The Patrician Malady," by Roy Porter and G. S. Rousseau, and that's good enough for me.
Both Hańska and Balzac took ill after the wedding; she suffered from a severe attack of gout, for which her doctor prescribed an unusual treatment: "Every other day she has to thrust her feet into the body of a sucking-pig which has only just been slit open, because it is necessary that the entrails should be quivering".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com