Unlike their undifferentiated progenitors, these spermatogonia are irreversibly committed to eventually enter meiosis and further divisions and development of these cells are strictly orchestrated by the stages of the seminiferous epithelium.
Improper clearance of apoptotic debris through their opsonization by maternal antibodies and subsequent removal by macrophages may lead to a sustained inflammation in the fetal heart, eventually damaging the developing organ irreversibly.
While COP has relatively good prognosis among IIPs, IPF and fibrotic NSIP progress irreversibly with most patients eventually dying because of respiratory insufficiency [ 2, 3].
Although some single QDs exhibit long-lasting PL emission, they all eventually undergo a blue-shift and irreversibly lose their PL.
Alpha-Bungarotoxin is a toxic substance in krait snake venom and can bind irreversibly to acetylcholine receptors and eventually lead to death in victims [ 257, 258].
The observed decrease of mitochondrial Ca2+, appears to be a compensatory attempt to prevent the mitochondrial Ca2+ stress that would irreversibly damage the organelles and eventually lead to cell death [69].
Finally, the pipet would become irreversibly blocked.
Zeratul attempts to rescue Raszagal, but the player prevents their escape, and Zeratul eventually kills Raszagal when it becomes clear she has been irreversibly brainwashed by Kerrigan.
Although Monica is initially frightened of David, she eventually warms enough to him to activate his imprinting protocol, which irreversibly causes David to have an enduring childlike love for her.
"The uprising that took place on the island of Santo Domingo (today Haiti and the Dominican Republic) during the night of 22 to 23 August 1791 shook the slave system radically and irreversibly and provided the impetus for the process which would eventually lead to the abolition of the transatlantic slave trade," according to Koïchiro Matsuura, former Director-General of UNESCO.
