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The reasons why the holding times during conditioning become eventually ineffective in promoting more α′ formation on cooling are discussed in terms of the differences in the potency of the embryos created in the δ matrix during conditioning and in terms of growth-impeding volume strains in the matrix resulting from an increasing number of martensite particles, thus opposing further growth.
In conclusion, the results presented here demonstrate that the same degree of β-secretase suppression (e.g., 50% by BACE1+/− deletion) becomes less efficacious and eventually ineffective in reducing Aβ/C99 accumulation and rescuing cholinergic neurodegeneration or memory deficits in 5XFAD mice as disease progresses into the more profound stage that is accompanied by BACE1 upregulation.
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Given sufficient time, these outliers will repopulate the full distribution of cells and render the treatment inefficient or eventually completely ineffective.
Those drugs, however, were eventually rendered ineffective by multidrug-resistant S. Typhi.
As the disease progresses and dopaminergic neurons continue to be lost, these drugs eventually become ineffective at treating the symptoms and at the same time produce a complication called dyskinesia, marked by involuntary writhing movements.
However, chronic therapy with a single TKI eventually becomes ineffective due to acquired mechanisms of resistance.
For example, human anti-chimeric antibodies are a significant cause of secondary inefficacy of infliximab, whereby mAb requirements increase with time and treatment may eventually become ineffective [ 13].
It will eventually become inefficient and ineffective to maintain the level of incentives.
City light pollution eventually rendered it ineffective, and the scope was moved to the Institute's Space Command exhibit.
Hydraulic fracturing from vertical wells subject to reverse faulting stress regimes is found to be problematic due to turning and twisting of propagating fractures, and eventually resulting in ineffective treatments to increase production.
However, addition of many non-local links eventually makes control ineffective.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com