After 7 days' culture, they formed into cystic EBs that would eventually differentiate into the three embryonic germ layers.
Since depletion of Nup358 results in the generation of multiple axons, one possible explanation could be that Nup358 negatively regulates axon formation by inhibition of aPKC at the neurites that eventually differentiate into the dendrites.
The secondary hair germ cells are the first to be activated during anagen initiation, giving rise to transient amplifying cells of the hair matrix and eventually differentiating into the hair shaft [ 15, 17, 18].
The intestinal crypts of Lieberkühn, a highly dynamic niche with multipotent stem cells residing in its lower third, generate new cells that eventually differentiate into the four specialized cell types of the small intestine, namely absorptive enterocytes and secretory lineages known as enteroendocrine, goblet and Paneth cells.
Remarkably, the remaining lens-averted domain of those embryos, which was ectopically localized and was not integrated into the optic cup, eventually differentiated into neuroretina, as indicated by the expression of vsx1 (Kimura et al., 2008; Shi et al., 2011; Vitorino et al., 2009) and vsx2 (formerly Chx10) (Vitorino et al., 2009).
Furthermore, we have introduced S-17 murine stromal cell lines to support the leukemic spleen cells in order to assess longer-term effect of treatment drugs, as the CD34+ population of leukemic cells from the NOG mice eventually differentiated into CD34− cells and could not be maintained only with cytokines for a longer period.
However, these cells failed to sustain the morphological characteristics and eventually differentiated into multinucleated cells as well as giant nuclear cells (Figure 1C).
Cells in the unstimulated marrow environment eventually differentiated into osteoblasts as well, but they did so in far fewer numbers, and only after considerable delay (n = 5; Fig. 2F).
OLC-derived GFP-positive cells could be identified in mineralizing tooth germs by immunohistochemistry. OLCs were capable of intercellular and cell-matrix communication, thus they eventually differentiated into functional odontoblasts.
Ectopic cell proliferation in AP2C3oe lines often produced almost isodiametric cells, which eventually differentiated into stomata suggesting that asymmetric cell divisions were not obligatory for stomata initiation.
