Variability: palpation, pressure algometry and cervical range of motion measurement were standardised at group meetings during the observation period to reduce eventual intertester and intratester variability.
Therefore, whilst quantification of such low levels following primary RNA isolation is challenging, we recommend that this is performed to allow subsequent input normalisation (as outlined in the current study) and eventual maximisation of ability to interrogate variability due to biology rather than technical parameters.
The external loading conditions derived from these models can ultimately be used to establish population variability in loading conditions, for eventual use in computational as well as experimental activity simulations.
To evaluate the impact of the variability in SCr measurements and its eventual clinical consequences in a real patient population, we used a cohort of 82424 patients aged 19 106 years.
Even the size of the eventual data set is robust to changes in exposure variability, as long as recruitment costs are small (table 2).
Irrespective of the extent of exposure variability, however, non-linear subject recruitment costs will affect the eventual size of the exposure data sample, and hence the precision of the resulting exposure mean value.
To investigate the impact of the variability in SCr measurements as found in the national EQA database and the eventual clinical consequences hereof in a real patient population, we used an unselected cohort of 82424 patients whose SCr had been measured in 2009 in the Isala Clinics Zwolle, the Netherlands; the details of this population have been described before [ 15].
The gradual reduction in variability is accompanied by an increase in speaking rate [6], [15], [18] and the eventual achievement of more adult-like acoustic and kinematic parameter values (e.g., mean vowel formant frequencies and movement amplitudes; [6], [15], [19], [20], [21]).
When individuals vary in their response to the novel stimulus, when this variability is heritable, and the stimulus is recurrent, such environmental induction can lead to eventual genetic determination of a novel adaptation [ 7, 8].
The large variability in dose prescription and in administration modality reflected the different physicians' attitudes and any eventual treatment adjustment in accordance with patient compliance.
