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As with all available therapies, eventual resistance to abiraterone acetate occurs.
Frequent relapses and eventual resistance to fludarabine characterize symptomatic CLL and portends a dismal prognosis for patients.
The results presented here could also be interpreted as a cause of the eventual resistance seen in response to endocrine therapy.
However, eventual resistance to these therapies is observed in the majority of cases, representing a major obstacle to long-term cures.
Further, AtCNGC4 is permeable to both K+ and Na+, is activated by both cGMP and cAMP and is induced in response to pathogen infection and some pathogen-related signals leading to the HR and eventual resistance [ 26].
Of interest, both this patient and patient #1 harbored FGFR1 aberrations and, as mentioned, FGFR1 can activate both PI3K and MAPK signals, hence potentially explaining both initial response to everolimus (via PI3K activation) and eventual resistance (via MAPK).
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To be a useful in construction, susceptibility to moisture and eventual moisture resistance is necessary.
Indeed, he suggests that in the naturally occurring obese agouti mutants, the abnormal production of the protein may in fact stimulate excess insulin production by the pancreas, which might then not only help cause the animals' weight gain, but also lead to their eventual insulin resistance and diabetes.
It is well established in C57 mice that consumption of HFD results in both moderate hyperglycemia and progressive hyperinsulinemia, leading to eventual insulin resistance [30].
Our results demonstrate that continuous, chronic exposure of C2 cells to TOC causes eventual drug resistance.
However, despite initial responses to therapy, relapse and eventual chemotherapy resistance usually occur in B-CLL patients.
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