Without the capacity to eliminate glutamate, OPCs and other cell types will be rendered even more vulnerable to damage and eventual cell death.
Lead toxicity is well known for causing oxidative stress in brain cells which can lead to damage and eventual cell death.
Therefore, mutation in the Cs gene might be expected to have deleterious effects on mitochondrial function, leading to progressively impaired energy metabolism, continuous ROS production, oxidative damage, and eventual cell death (Balaban et al., 2005; Dirks et al., 2006).
Taken together, our data provide evidence that metergoline elicited cell death process in C. krusei through elevation of the intracellular ROS level and perturbation of mitochondrial homeostasis, followed by damage of nucleus and eventual cell demise.
Most of the neural cell types are capable of degrading free or small, oligomeric a-Syn species; thus, the influx of these a-Syn aggregate species could potentially start the intracellular, pathological cycle of a-Syn aggregation, cell damage and death, and the eventual release of additional toxic forms of a-Syn to nearby cells [ 36, 37, 55, 56].
For example, metal cations, such as iron, copper, and chromium, have been implicated in production of elevated levels of reactive oxygen species which can lead to DNA damage, lipid peroxidation, protein oxidation, and eventual cell death [ 16- 18].
Double-isotope labelling in conjunction with hydroxyapatite chromatography allowed the evaluation of drug effects on initiation of DNA replicons, DNA chain elongation and DNA damage (single-strand breaks), and their correlation with eventual cell viability.
The results from fluorescence spectroscopy and transmission electron microscopy (TEM) suggested that Py11 kills bacterial cells possibly by integrity disruption damaging the cell membrane, leading to the cytosol leakage and eventual cell lysis.
Expression of 2Apro resulted in significant morphological alteration and eventual cell death.
MTT results clearly indicated that mineralized scaffolds did not inhibit the eventual cell proliferation.
