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The attending veterinarian recorded details of all welfare matters, including protocol deviations, suspected adverse events, development of concurrent medical problems and euthanasia.
Rates of first distant metastasis were calculated as number of events (development of first distant metastasis) divided by total risk time.
The final end point used for power calculations will be the composite end points of cardiovascular mortality, cardiovascular events, development of cancer, and development of hypoglycemia.
Based on collected and registry data, the following results will be used for evaluation of the metabolic profile of the cohort: mortality rate, cardiovascular mortality, mortality due to cancer, cardiovascular events, development of microvascular complications, metabolic status (hemoglobin A1c [Hband] and lipid profile) and current medication.
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Major themes with associated subthemes identified are summarised in figure 1 and were: PE as a life-changing event, development of PTSD and identification of support needs.
Within the captured flow of events, development activities comprised of several events are recognized.
Safety was evaluated by the occurrence of related adverse events, and immunogenic events, including development of inhibitors.
Data suggest that NP22 may play a role in mediating the molecular events governing development of the neuronal architecture.
Luo, W. et al. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.
The mechanisms by which prenatal events affect development of adult disease are incompletely characterized.
Studies conducted in mutant SOD1 transgenic mouse models indicate that loss of synaptic connections, leading to nerve retraction, are early events in development of pathological phenotypes [35] [37].
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