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The Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) aimed to assess gastrointestinal and cardiovascular safety of the COX2 inhibitor lumiracoxib compared with two non-steroidal anti-inflammatory drugs, naproxen and ibuprofen.
Third, QUIET (QUinapril Ischemic Event Trial), 43 which included low-risk patients, found no significant benefit.
The application of a continuity correction to the zero event trial neither changed the estimate nor the confidence interval.
Application of an empirical continuity correction of 0.01 in the no event trial did not change the result.
In the Random Pattern, stimuli and long breaks (4000 ms) were randomly dispersed throughout a 415 event trial (totaling 332 stimuli and 83 breaks).
The PEACH study is based on an innovative 'telephone coaching' program that has been used effectively in a post cardiac event trial.
Similar(50)
A sensitivity analysis including zero event trials will be conducted with an application of constant continuity correction to the no-event trial.
However, in these examples the treatment effect was similar between zero total event trials and event trials.
Including the zero total event trials reduces the magnitude of the treatment effect.
The addition of zero total event trials decreased heterogeneity in the examples provided.
Continuity correction was not required as no zero event trials were identified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com