In DML1 gene, both duplication events, loci AT2G36490-AT3G10010 (DML1-DML2) (Ks value 2.69) and loci AT2G36490- AT5G04560 (DML1-DML3) (Ks value 2.69), seemed to occur in very close time span while DML3 and DML2 were sharing same node on phylogenetic tree probably because of old duplication event by which these two non-duplicates come closer than DML1.
This implies that increased non-coding transcription is not essential for histone hyper-acetylation at these loci; it also indicates that acetylation is an early event in locus activation.
Time course experiments showed that the demethylation event is locus-specific, and is coupled with dynamic changes in the DNA methylation machinery, including TET2, DNMT1, DNMT3A and DNMT3B.
According to Charlesworth et al. 76, assuming a population size of no more than 100 diploid individuals and a chromosome with 1,000 loci, 10−5 cross-over events per locus and generation are sufficient (for review see 62).
To address this question, and determine the critical events in locus activation that control RSS accessibility, our strategy was to activate V(D J recombination and then analyse the cascade of events that follow.
The number of repeats per mutational event across loci was assumed to follow a geometric distribution with a uniform prior for the parameter P ranging from 0.1 to 0.6, whereas P for individual loci followed a Gamma distribution with mean determined by mean across loci and prior ranging from 10-2 to 9 × 10-1.
Deformation is common (24% of all potentially magmatic events) at loci ≥5 km away from the nearest active volcanic vent.
Recombination events between loci accumulate with the advance of the intercross generations.
CharacTErizer cannot automatically identify precise excision events in loci designated as heterozygous because a perfect excision spanner is indistinguishable from a spanner of an absent TE insertion.
In the event that a locus containing multiple isoforms did not return a significant hit, the longest transcript was chosen to represent its locus.
