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Most of this vast region of 300,000 square miles (800,000 square km) was still unoccupied and even unexplored by Europeans.
Although these studies have shed some light on the evolutionary forces acting on TFBS and other regulatory elements, several issues remain poorly explored or even unexplored.
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A 2003 study in the journal Ecosystems estimated that the biodiversity of nearly 5 percent of the nation's soil was "in danger of substantial loss, or complete extinction, due to agriculture and urbanization," though that was most likely a very conservative guess, since the planet's soil was even more unexplored then than today, and study techniques were far less developed.
The kind of dream that changes everything: Civil rights, rampant corporate corruption, a British King's stranglehold on a colony across the Atlantic, global warming, a world economy in crisis, even the unexplored cosmos which opens itself up to us every night in our dreams?
These mechanisms may include regulation at the transcriptional, posttranscriptional, and posttranslational levels or even some unexplored mechanisms that may include regulation by microRNAs (miRNA) and epigenetic mechanisms [ 7].
But there are still plenty of Slavic highways and byways unexplored even by this indefatigable musician.
No aspect of the musical experience is left unexplored, even its political dimension.
It is a remote spot, rarely visited by tourists and unexplored even by experienced climbers or other extreme-sport athletes.
This issue remains unexplored even though the same threats to internal validity operate as for studies with nongenetic information.
Response in lung volumes remains largely unexplored even though volume parameters, such as inspiratory capacity (IC), closely correlate with functional improvements.
This topic is a mainstream issue in the field of ecological economics, but its application to fisheries is rather unexplored, even though fisheries have been the focus of many pioneering studies related to natural resource management.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com