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A more recent study has confirmed the efficacy of losartan treatment in improving aortic wall degeneration in Fbn1 mgR/mgR mice, a more severe model of MFS than the Fbn1 C1039G/+ mouse, even though the regimen showed no beneficial impact to counteract bone loss [ 49].
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It was also found that even though the dosing regimen 4 mg/kg every 24 h produces lower peaks in preterm neonates, the bactericidal effect may be sufficient.
Even though the Yuzpe regimen has become an established and recommended method of emergency contraception, there is a need to reduce the incidence of adverse effects while maintaining effectiveness [ 9].
6 53 Meta-analysis of randomised controlled trials comparing divided lower doses of IVIG (400 mg/kg/day for four consecutive days) versus a single infusion of high-dose IVIG (2 g/kg over 10 h) has shown that even though the 4-day regimen has some benefit, the single-dose regimen has a greater therapeutic effect in the prevention of CAA.
Even though the two-dose regimen is favored around the world, the NIID recommendation was considered the best possible rapid option under laws governing immunization regulations.
Furthermore, chemotherapy treatments were not homogeneous even though the majority of regimens consisted of fluoropyrimidine-based chemotherapy.
(2) Curative AML (induction) treatment is not standardized and the regimens that we used in our study are—even though used frequently not necessarily representative of AML induction regimens used in other parts of the world or in different study groups.
We provided all the meals during the whole study for one half of the participants in order to ensure the best possible compliance, yet we have to admit the possibility of a reduced energy intake with the B2 regimen, even though the energy intake reported by our participants was similar in both regimens.
In most states, doctors have been following the medically accepted regimen, even though the label advised otherwise, a fairly common medical practice known as off-label use.
Topoisomerase IIα has therefore become the main target of many antitumour therapy regimens, even though the exact mechanism of cell killing remains elusive.
While no effect of previous chemotherapy on PFS was seen, there was some indication of a shorter survival in patients who had received adjuvant chemotherapy, and particularly anthracyclines-containing regimens, even though the difference fell short of statistical significance.
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