These well-established epigenetic mechanisms, including DNA methylation, histone modifications, and miRNAs, are essential for normal development and are now intimately linked to disease phenotypes through their involvement in the regulation of gene transcription.
Coke's mother, Winifred Knightley, came from a family even more intimately linked with the law than her husband.
Book sales here are increasing at about 5 percent a year, according to PricewaterhouseCoopers. "What we see now is intimately linked to the economic growth," said Mr. Chandra, who teaches creative writing at the University of California, Berkeley.
Conversely, links to soil gas diffusivity (Dp/Do) have not been fully explored even though gas diffusivity is intimately linked to the connectivity and tortuosity of the soil pore network.
Fixation is a key step in the practice of diagnostic pathology, and even in modern times, is intimately linked to the use of formaldehyde (HCHO), a gas commercially available in concentrated solution (37%), stabilized with ethanol, and named Formalin.
Transcription termination occurs up to several hundred bases downstream of the 3′ end processing site even though both processes are intimately linked and mutation of many 3′ end processing factors results in transcription termination defects [48,76,93,98,102 105].
Increasing emphasis is now being placed on rapid response intimately linked to rapid assessment, with some sound outcomes derived from this strategy being reported.
Evidence now suggests that demethylation of silencing modifications is intimately linked to the deposition of histone-activating events to promote the relaxation of the repressive nature of chromatin [ 14, 15, 47, 48].
By Sasha Frere-Jones For five hundred years, Angola was a colony of Portugal; even after it achieved independence, in 1975, the two countries remained intimately linked.
For five hundred years, Angola was a colony of Portugal; even after it achieved independence, in 1975, the two countries remained intimately linked.
Our work has shown that even in the first year of school, language and behaviour problems are intimately linked.
