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Thus, further inclusion of a Bcl-2 or Mcl-1 inhibitor to this regimen may result in even more efficacious anticancer efficacy than the combination of LBH589 and TRAIL and should be further explored.
However, regulators should be encouraged to also use more effectively the other tools in their toolboxes, many of which may be even more efficacious than capital, and when added to sound capital rules make for a truly sound regulatory platform.
The introduction of anthracyclines and, recently, taxanes has significantly improved the efficacy of adjuvant chemotherapy and has provided useful insight regarding future development of even more efficacious regimens.
Additionally, the level of Yap expression/activation in adult cardiac progenitor cells is not known and it would be interesting to determine whether Yap could serve as a marker of cardiac progenitors, similar to c-kit, Islet-1, Sca-1 etc., that proves even more efficacious and overcomes the limitations of those populations being isolated and used currently [147].
18 compounds were found to increase β-galactosidase activity at 10 µM and two compounds (Cpd4 and 5 in Figure S3) were even more efficacious than Cpd1.
KD025 appeared even more efficacious in females (42% reduction in infarct volume).
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For many PWID, hepatitis C is not a priority – and may still not be even with the advent of more efficacious treatments.
The current paucity of effective and well tolerated drug treatments and even more so, the lack of highly efficacious, well standardized and widely available vaccination strategies can be attributed at least in part to the gap of knowledge about the intricate interplay between leishmania and host macrophages.
In this context, targeting mutant or hyperactivated molecules to elicit specific apoptosis of leukaemia cells would be a rational approach for more efficacious therapy and may even result in complete remission.
2 Even with prolonged treatment, recurrence rates are high, and a more efficacious treatment regimen is needed.
Even low-dose ibuprofen (400 mg/day) was found to be significantly more efficacious than high-dose acetaminophen in one large-scale trial [ 50].
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even more successful
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