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We have faced even more difficult problems than this one.
The simulations in this paper represent even more difficult problems for the inference methods.
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String theory had already failed in its first incarnation as a description of the strong force, and many felt it was unlikely that it would now prevail as the solution to an even more difficult problem.
However, due to the non-uniform cost/size property of data objects in this environment, design of an efficient caching algorithm becomes an even more difficult problem compared to the traditional caching problems.
Solving this problem and visiting the advertised (now defunct) web site led to an even more difficult problem to solve, which in turn led to Google Labs where the visitor was invited to submit a resume.
Predicting functional binding is an even more difficult problem.
This is an even more difficult problem in non-model fish species with totally unknown genome sequences.
In addition, an even more difficult problem is to understand the biological significance of the patterns found in the datasets.
It should be noted that mechanisms of massive intron gain events (for example, in the earliest eukaryotes [ 148, 275] could well be different from mechanisms of relatively slow intron acquisition process in various extant eukaryotes [ 66, 94, 96, 273] which makes delineation of mechanisms of intron gains an even more difficult problem.
Reinvest it to solve an even more difficult problem or win a more advanced game.
The European Union, too, faces this challenge — a challenge made even more difficult by problems arising from a hasty E.U. enlargement and monetary integration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com