MLFD remains log-concave if truncated.
Even if these truncated BES are not functional, they may still contribute sequences via gene conversion to other BESs.
Nevertheless, given that the NTE is necessary for the activity of some full-molecule ABC transporters, we suspect that even if a truncated polypeptide were generated in this mutant allele, it would not be functional [23], [24].
Therefore, even if a truncated protein lacking Sec is stable, it will not be biologically active.
Even if in previous studies truncated forms of CREI have been investigated, interestingly, none of them reported a positive effect of the shorter CREI version compared to a deletion of CREI.
Since NMD may degrade the SOD1 mRNA with PTC in exons other than exon 5, leading to a significantly reduced protein amount, therefore, an insufficient amount of the mutant protein may not be able to cause the disease, even if a C-terminal truncated SOD1 polypeptide has ALS-associated toxicity.
The truncated protein, even if present in a small amount, could contribute to the pathological changes in this patient's skin.
Here is a small piece of the puzzle (if Wagner, even truncated, can ever be called small), as he conducts the orchestra in a concert performance of the Act I Prelude, all of Act II and the Act III Prelude and "Liebestod".
We considered each of these peptides to be distinct, even if they were a series of truncated forms from one peptide, because even these seemingly small changes may have biologically relevant consequences.
If it was truncated or truncating, why not think twice to do anything about it?
