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Moreover, even if differentiated leech muscle fibres are able to divide in a very peculiar manner [35], this slow process cannot be considered an efficient system for a rapid re-establishment of the muscular body wall.
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A recent study could demonstrate that peripheral undifferentiated sarcomas with MDM2 amplification correspond to DDLPS, even if a well-differentiated component was not present [ 12].
Such local knowledge is critical for adaptation to climate variability and change because formal regulations alone, even if they are regionally differentiated, cannot sufficiently capture the local differences and changes in climatic conditions (Eriksen and others 2009).
Niches allow the repopulation of the stem cell compartment from migrating stem cells or even from differentiated cells if the stem cell compartment is depleted [ 47- 49].
In particular, survivin expression often increased in poorly differentiated tumours, even if differences were not statistically significant.
Pituitary adenomas are generally well differentiated neoplasms, even if in about one third of cases they are invasive of surrounding tissues.
Even if cancer cells, especially poorly differentiated cancer cells, lose polarity, cancer cells communicate with stromal cells mostly via extracellular matrix, which can be mimicked by this system.
However, a recent study reported that peripheral UPS with MDM2 gene amplification is considered DDLS even if there is no well-differentiated liposarcoma area [ 23].
In multicellular organisms, especially the first type of mechanisms can explain how differentiated cells give rise to identical daughter cells even if the signal that initiated differentiation is gone.
Even more differentiated was the engagement of the "external" cardinals in the Church government and the papal policy, even if limited evidence does not fully highlight this question.
These findings suggest that the patients with a higher SUVmax of the primary renal tumor should be under active surveillance, even if the tumor is well or moderately differentiated or is a noninvasive T1 lesion.
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