Exact(2)
This is particularly problematic in the context of poorly resourced healthcare settings where even efficacious interventions fail to translate into improvements in health.
However, JAK inhibitors were reported to inhibit the activation of many types of inflammatory cells, including B cells, neutrophils, and macrophages, as well as that of T cells [ 12, 23, 24], indicating that JAK inhibition by JAK inhibitors is even efficacious when the inhibitors are administered after the onset of arthritis.
Similar(57)
Thus, further inclusion of a Bcl-2 or Mcl-1 inhibitor to this regimen may result in even more efficacious anticancer efficacy than the combination of LBH589 and TRAIL and should be further explored.
However, regulators should be encouraged to also use more effectively the other tools in their toolboxes, many of which may be even more efficacious than capital, and when added to sound capital rules make for a truly sound regulatory platform.
The introduction of anthracyclines and, recently, taxanes has significantly improved the efficacy of adjuvant chemotherapy and has provided useful insight regarding future development of even more efficacious regimens.
In patients with fibromyalgia systemic administration of tropisetron (5 mg), reduced pain intensity, tender-point count and improved sleep [19, 20], indicating that 5-HT3-receptor antagonists might even be efficacious in more generalized pain conditions, such as fibromyalgia.
Additionally, the level of Yap expression/activation in adult cardiac progenitor cells is not known and it would be interesting to determine whether Yap could serve as a marker of cardiac progenitors, similar to c-kit, Islet-1, Sca-1 etc., that proves even more efficacious and overcomes the limitations of those populations being isolated and used currently [147].
18 compounds were found to increase β-galactosidase activity at 10 µM and two compounds (Cpd4 and 5 in Figure S3) were even more efficacious than Cpd1.
KD025 appeared even more efficacious in females (42% reduction in infarct volume).
The emergence of device-related infections caused by Achromobacter may be intractable, even when efficacious antibiotics are administered.
However, even an efficacious intervention that reaches many people will have limited impact over time, unless it is Adopted, Implemented, and Maintained.
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