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This is consistent with the recent findings showing that even a subtle decrease in PTEN dose increased cancer susceptibility in mice, affected the cellular proliferation particularly in mouse mammary tissue, and altered the expression of proliferation related genes [ 31].
However, even a subtle decrease in PLD3 expression and function could cause production of greater amounts of amyloidogenic species of Aβ, in view of the evidence that PLD3 acts as a negative regulator of APP processing [ 5].
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Healthy vagal function is reflected in a subtle increase in heart rate while breathing in and a subtle decrease while breathing out.
These results indicate that disease-causing mutations in Rab7 cause a subtle decrease in the rate of membrane exchange.
The ophthalmological examination revealed only a subtle decrease of the peripheral visual field and optic nerve pallor.
The mean gray values of the H3K9me2 signals revealed a subtle decrease in H3K9me2 following chromatin condensation.
In the presence of ANP or sildenafil alone, there was a subtle decrease in the degree of αSMA accumulation.
Thus, the failure of the Vps35 pathogenic variants to fully rescue this phenotype likely reflects a subtle decrease in functionality.
Herein, we demonstrate that even a subtle change in the molecular structure affects the kinetic behavior of metastable supramolecular assembles.
Even a subtle mistake can leave you with an ugly array of bruises.
The results suggest that even a subtle shift by the media could have profound effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com