The work of Boerner et al. suggests not only that formation of the SC is not involved but that SC polymerization may even be a consequence of interference rather than its cause.
Yet these very prizings may be subject to appraisal at some other time, perhaps even as a consequence of acting on them on this occasion.
The second barrier, GP perceptions of the unreliability of patient alcohol use histories, can be seen as interacting with, and perhaps, even as a consequence of the first.
Hence, strong apical enlargement is not a prerequisite for cell segregation and it may even be a consequence of nearby apical constriction.
Additionally, this relationship has been found (Haier et al. 1992) even as a consequence of "Tetris" learning effects, which were associated with a decrease of local glucose metabolic rates.
Their results suggested that the bone marrow might be involved in the toxicity profile, but it remained unclear whether the toxicity was directly due to the absence of these drug transporters in the haematopoietic progenitor cells or whether it was also, or even merely, a consequence of a reduced drug clearance in these Mdr1ab/Mrp1 triple KO mice.
Indeed, the study of bone turnover markers in acute Charcot neuroarthropathy shows that there is an increase in osteoclast activity compared with osteoblast activity (9); this can lead to osteopenia, which could predispose to fracture, even as a consequence of minimal trauma.
On the whole, patients with concomitant RA and HCV infection require the same clinical assessment and monitoring as patients with HCV-associated arthritis with or without MCs; they may have an increased risk to develop some HCV-associated complications, such as B-cell NHL, even as a consequence of immunomodulating therapies.
These findings could be interpreted to suggest that environmentally relevant concentrations of diclofenac could alter gene expression in fish, but it is unclear whether these genes would also be induced upon exposure to any pharmaceutical, or even as a consequence of something unrelated to drug exposure.
The increase in sHA concentration with age may even be a consequence of progressive age-related hepatic and renal impairment [ 29]. sHA concentration is reported to be influenced by other factors, including renal failure [ 30], liver failure [ 31], rheumatoid arthritis [ 32], malignancy [ 33], and physical activity [ 34].
